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DOP01: Efficacy and safety of the IL-6 trans-signalling inhibitor olamkicept: a phase 2 randomized, placebo-controlled trial in moderately to severely active Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Chen, B.(1);Zhang, S.(1);Wang, B.(2);Chen, H.(3);Li, Y.(4);Cao, Q.(5);Zhong, J.(6);Xie, M.(7);Ran, Z.(8);Tang, T.(9);Yang, M.(10);Guo, T.(10);Xu, B.(10);Cai, Z.(10);Schreiber, S.(11);Chen, M.(1);
(1)The First Affiliated Hospital of Sun Yat-sen University, gastroenterology department, Guangzhou, China;(2)Tianjin Medical University General Hospital, gastroenterology department, Tianjin, China;(3)Zhongda Hospital Affiliated to Southeast University, gastroenterology department, Nanjing, China;(4)Shengjing Hospital affiliated to China Medical University, gastroenterology department, Shenyang, China;(5)Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, gastroenterology department, Hangzhou, China;(6)Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, gastroenterology department, Shanghai, China;(7)National Taiwan University Hospital, gastroenterology department, Taibei, China;(8)Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, gastroenterology department, Shanghai, China;(9)The First Hospital of Jilin University, gastroenterology department, Changchun, China;(10)I-Mab Biopharma, Research and Development, Shanghai, China;(11)University Hospital Schleswig-Holstein, Department Medicine I, Kiel, Germany
DOP02: αEβ7 positive γδ T cells are associated with mucosal healing in Ulcerative Colitis and have a homeostatic immunophenotypeECCO'21 Virtual
Year: 2021
Authors: Dart, R.(1,2);Zlatareva, I.(1,2);Irving, P.(1,3);Hayday, A.(1,2)
(1)King's College London, Peter Gorer Department of Immunobiology, London, United Kingdom;(2)Francis Crick Institute, Immunosurveillance Lab, London, United Kingdom;(3)Guy's and St Thomas Hospital, Department of Gastroenterology, London, United Kingdom
DOP03: Early change in epithelial neutrophilic infiltrate predicts long-term response to biologics in Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Narula, N.(1);Wong, E.(1);Colombel, J.F.(2);Riddell, R.(3);Marshall, J.(4);Reinisch, W.(5);Dulai, P.(6)
(1)McMaster University, Department of Medicine- Division of Gastroenterology, Hamilton, Canada;(2)Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States;(3)Mount Sinai Hospital, Department of Pathology and Laboratory Medicine, Toronto, Canada;(4)McMaster University, Department of Gastroenterology, Hamilton, Canada;(5)Medical University of Vienna, Department of Internal Medicine III- Division of Gastroenterology and Hepatology, Vienna, Austria;(6)University of California San Diego, Division of Gastroenterology, La Jolla, United States
DOP04: Single cell RNA sequencing identifies distinct intestinal inflammation patterns between primary sclerosing cholangitis-associated colitis and Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Uniken Venema, W.(1);Bangma, A.(1);Van der Wijst, M.(2);Kats-Ugurlu, G.(1);Bjork, J.(1);Vich Vila, A.(1);Weersma, R.(1);Festen, E.(1)
(1)University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University Medical Center Groningen, Department of Clinical Genetics, Groningen, The Netherlands
DOP05: Target engagement and pharmacodynamic biomarker analysis following treatment with the oral gut-targeted HIF-1α stabilizer GB004 in a Phase 1b trial in Active Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Sandborn, W.(1);Ding, Z.(2);Osterhout, R.(2);Feagan, B.(3);Danese, S.(4);Jucov, A.(5,6);Bhandari, B.R.(7);Raghupathi, K.(8);Olson, A.(9);Van Biene, C.(8);Ford, J.(10);Aranda, R.(9);Levesque, B.G.(9);Bruey, J.M.(2)
(1)University of California San Diego, Gastroenterology, San Diego, United States;(2)Gossamer Bio- Inc., Translational Medicine, San Diego, United States;(3)Western University- Alimentiv- Inc., Gastroenterology, London, Canada;(4)Humanitas Research and Teaching Hospital, Gastroenterology, Milan, Italy;(5)ARENSIA Exploratory Medicine GmbH, Gastroenterology, Dusseldorf, Germany;(6)Nicolae Testemițanu State University of Medicine and Pharmacy, Gastroenterology, Chișinău, Moldova- Republic Of;(7)Delta Research Partners, Gastroenterology, Bastrop, United States;(8)Gossamer Bio- Inc., Biometrics, San Diego, United States;(9)Gossamer Bio- Inc., Clinical Development, San Diego, United States;(10)Gossamer Bio- Inc., Clinical Operations, San Diego, United States
DOP06: Histologic activity in Ulcerative Colitis patients achieving endoscopic healing is associated with higher rate of relapse and a distinct mucosal microbial and transcriptional profileECCO'21 Virtual
Year: 2021
Authors: Hernandez-Rocha, C.(1);Turpin, W.(2);Nayeri, S.(3);Borowski, K.(3);Stempak, J.(3);Conner, J.(4);Silverberg, M.S.(1)
(1)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Division of Gastroenterology- Mount Sinai Hospital- University of Toronto, Toronto- ON, Canada;(2)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute- Sinai Health System, Department of Medicine- University of Toronto, Toronto- ON, Canada;(3)Zane Cohen Centre for Digestive Diseases- Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto- ON, Canada;(4)Department of Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto- ON, Canada
DOP07: Ulcerative Colitis associated single nucleotide polymorphisms found in transcription factor binding sites effect key pathogenesis pathways and facilitate patient stratificationECCO'21 Virtual
Year: 2021
Authors: Modos, D.(1,2,3);Brooks-Warburton, J.(1,3,4,5,6,7);Sudhakar, P.(1,3,8);Madgwick, M.(1,3);Fazekas, D.(3,9);Szalay-Beko, M.(3);Thomas, J.P.(3,7);Verstockt, B.(8,10);Watson, A.(6,7);Tremelling, M.(7);Parkes, M.(11);Vermeire, S.(8,10);Bender, A.(2);Carding, S.R.(1,6);Korcsmaros, T.(1,3)
(1)Quadram Institute Bioscience, Gut Microbes and Health Programme, Norwich, United Kingdom;(2)University of Cambridge, Department of Chemistry, Cambridge, United Kingdom;(3)Earlahm Institute, Earlahm Institute, Norwich, United Kingdom;(4)University of Hertfordshire-, Department of Clinical- Pharmaceutical and Biological Sciences, Hertford, United Kingdom;(5)Lister Hospital, Department of Gastroenterology, Stevenage, United Kingdom;(6)University of East Anglia, Norwich Medical School, Norwich, United Kingdom;(7)Norfolk and Norwich University Hospitals, Department of Gastroenterology, Norwich, United Kingdom;(8)KU Leuven, Department of Chronic diseases- Metabolism and Ageing, Leuven, Belgium;(9)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;(10)KU Leuven, University Hospitals Leuven- Department of Gastroenterology and Hepatology, Leuven, Belgium;(11)University of Cambridge, Inflammatory Bowel Disease Research Group- Addenbrooke's Hospital, Cambridge, United Kingdom
DOP08: Serum proteomics predict endoscopic remission in patients with Crohn’s DiseaseECCO'21 Virtual
Year: 2021
Authors: Alsoud, D.(1);Sudhakar, P.(1);Sabino, J.(1,2);Ferrante , M.(1,2);Verstockt , B.(1,2);Vermeire, S.(1,2)
(1)KU Leuven, Translational Research Center for GastroIntestinal Disorders- Department of Chronic Diseases- Metabolism and Ageing, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium
DOP09: Mirikizumab-induced transcriptome changes in patient biopsies at Week 12 are maintained through Week 52 in patients with Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Johnson, T.(1);Steere, B.(2);Zhang, P.(1);Zang, Y.(1);Higgs, R.(2);Gottlieb, K.(2);Reinisch, W.(3);Panés, J.(4);Krishnan, G.(2)
(1)Indiana University School of Medicine, IU Clinical and Translational Sciences Institute, Indianapolis, United States;(2)Eli Lilly and Company, Biomedicines, Indianapolis, United States;(3)Medical University Vienna, Internal Medicine, Vienna, Austria;(4)Hospital Clinic of Barcelona, Gastroenterology, Barcelona, Spain
DOP10: Persistent sonographic Inflammation as a predictor of clinical complications in patients with Crohn’s DiseaseECCO'21 Virtual
Year: 2021
Authors: Vaughan, R.(1);Tjandra, D.(1);Patwardhan, A.(1);Mingos, N.(1);Gibson, R.(2);Boussioutas, A.(1);Christensen, B.(1)
(1)The Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia;(2)The Royal Melbourne Hospital, Radiology, Melbourne, Australia
DOP11: Fibrosis and MAGNIFI-CD activity-index at MRI to predict treatment outcome in perianal fistulising Crohn’s Disease patientsECCO'21 Virtual
Year: 2021
Authors: Van Rijn, K.(1);Meima-van Praag, E.(2);Bossuyt, P.(3);D'Haens, G.(4);Horsthuis, K.(5);Snijder, H.(2);Tielbeek, J.(1);Buskens, C.(2);Stoker, J.(1)
(1)Amsterdam UMC- University of Amsterdam, Radiology and Nuclear Medicine, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Surgery, Amsterdam, The Netherlands;(3)Amsterdam UMC- University of Amsterdam, Epidemiology and Data Science, Amsterdam, The Netherlands;(4)Amsterdam UMC- University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(5)Amsterdam UMC- Vrije Universiteit, Radiology and Nuclear Medicine, Amsterdam, The Netherlands
DOP12: Validation of a modified simple ultrasound activity Score for children with Crohn’s DiseaseECCO'21 Virtual
Year: 2021
Authors: Ma, H.(1);Isaac, D.M.(1);Petrova, A.(1);Almeida, P.(1);Parsons, D.(1);Kuc, A.(1);Carroll, M.W.(1);Wine, E.(1);HuynhDr, H.(2)
(1)University of Alberta, Department of Paediatrics- Gastroenterology and Nutrition, Edmonton, Canada;(2)University of Alberta, Department of Paediatrics- Division of Gastroenterology and Nutrition, Edmonton, Canada
DOP13: Artificial Intelligence (AI) in endoscopy - Deep learning for detection and scoring of Ulcerative Colitis (UC) disease activity under multiple scoring systemsECCO'21 Virtual
Year: 2021
Authors: Byrne, M.(1);East, J.(2);Iacucci, M.(3);Panaccione, R.(4);Kalapala, R.(5);Duvvur, N.(5);Rughwani, H.(5);Singh, A.(5);Henkel, M.(6);Canaran, L.(7);Laage, G.(7);St-Denis, L.(7);Nikfal, S.(7);Asselin, J.(7);Monsurate, R.(8);Cremonese, E.(7);Soudan, F.(7);Travis, S.(9)
(1)Vancouver General Hospital, Division of Gastroenterology, Vancouver, Canada;(2)John Radcliffe Hospital, Gastroenterology, Oxford- Oxfordshire, United Kingdom;(3)Institute of Translational of Medicine Immunology & Immunotherapy, Gastroenterology, Birmingham, United Kingdom;(4)University of Calgary, Gastroenterology, Calgary- AB, Canada;(5)Asian Institute of Gastroenterology, Gastroenterology, Hyderabad- Telangana, India;(6)University of Buenos Aires, Gastroenterology, Buenos Aires, Argentina;(7)Ivado Labs, Artificial Intelligence, Montreal- QC, Canada;(8)University of British Columbia, Business Administration, Vancouver- BC, Canada;(9)University of Oxford, Medical Sciences Division, Oxford- Oxfordshire, United Kingdom
DOP14: Ultra-high magnification endocytoscopy and molecular markers for defining endoscopic and histologic remission in Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Iacucci, M.(1,2,3);Nardone, O.M.(1);Jeffery, L.(1);Acharjee, A.(4);Zardo, D.(5);Smith, S.C.(1);Bazarova, A.(6);Cannatelli, R.(1);Shivaji, U.N.(1);Williams, J.(4);Georgios, G.(4);Ghosh, S.(1,2,3)
(1)University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom;(2)University of Birmingham, NIHR Biomedical Research Centre, Birmingham, United Kingdom;(3)University Hospitals Birmingham NHS Trust, NIHR Wellcome Trust Clinical Research Facilities, Birmingham, United Kingdom;(4)University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom;(5)University Hospitals Birmingham NHS Trust, Department of Pathology, Birmingham, United Kingdom;(6)University of Cologne, Institute for Biological Physics, Cologne, Germany
DOP15: Clinical relevance of endoscopic peri-appendiceal red patch in Ulcerative Colitis patientsECCO'21 Virtual
Year: 2021
Authors: Reijntjes, M.(1);Heuthorst, L.(1);Gecse, K.(2);Mookhoek, A.(3);Bemelman, W.(1);Buskens, C.(1)
(1)Amsterdam UMC- location AMC, Surgery, Amsterdam, The Netherlands;(2)Amsterdam UMC- location AMC, Gastro-enterology, Amsterdam, The Netherlands;(3)Amsterdam UMC- location AMC, Pathology, Amsterdam, The Netherlands
DOP16: The ratio of submucosa thickness to the total bowel wall thickness can be a sonographic parameter to estimate endoscopic remission in Ulcerative ColitisECCO'21 Virtual
Year: 2021
Authors: Miyoshi, J.(1);Ozaki, R.(1);Yonezawa, H.(1);Mori, H.(1);Kawamura, N.(1);Matsuura, M.(1);Hisamatsu, T.(1)
(1)Kyorin University School of Medicine, Department of Gastroenterology and Hepatology, Mitaka-shi, Japan
DOP17: In high-risk Crohn’s Disease patients, anastomosis configuration types have similar rates of endoscopic recurrenceECCO'21 Virtual
Year: 2021
Authors: Bachour, S.(1);Shah, R.(1);Lyu, R.(2);Rieder, F.(1);Cohen, B.(1);Qazi, T.(1);Lashner, B.(1);Lipman, J.(3);Regueiro, M.(1);Lightner, A.(3);Holubar, S.(3);Click, B.(1)
(1)Cleveland Clinic Foundation, Department of Gastroenterology and Hepatology, Cleveland, United States;(2)Cleveland Clinic Foundation, Department of Quantitative Health Sciences, Cleveland, United States;(3)Cleveland Clinic Foundation, Department of Colorectal Surgery, Cleveland, United States
DOP18: UCEIS is associated with PRO2, partial Mayo and SCCAI remission in UC: Final results from a prospective studyECCO'21 Virtual
Year: 2021
Authors: Golovics, P.(1);Gonczi, L.(2);Reinglas, J.(3);Verdon, C.(3);Pundir, S.(3);Afif, W.(3);Wild, G.(3);Bitton, A.(3);Bessissow, T.(3);Lakatos, P.L.(3)
(1)HDF Medical Centre, Division of Gastroenterology, Budapest, Hungary;(2)Semmelweis University, 1st Department of Medicine, Budapest, Hungary;(3)McGill University Health Centre, Division of Gastroenterology, Montreal, Canada
DOP19: Urinary metabolome in newly diagnosed treatment-naïve Crohn’s Disease patients: Results from the IBDomics studyECCO'21 Virtual
Year: 2021
Authors: Aldars-García, L.(1);Gil-Redondo, R.(2);Embade, N.(2);Riestra, S.(3);Rivero, M.(4);Gutiérrez, A.(5);Rodríguez, I.(6);Fernández, L.(7);Ceballos, D.(8);Benítez, J.M.(9);Aguas, M.(10);Bastón-Rey, I.(11);Algaba, A.(12);Casanova, M.J.(1);Lorente, R.(13);Ber, Y.(14);Royo, V.(15);Esteve, M.(16);Millet, O.(2);Gisbert, J.P.(1);Chaparro, M.(1);
(1)Hospital Universitario de La Princesa IIS-P and CIBERehd, Gastroenterology, Madrid, Spain;(2)CIC bioGUNE, Precision Medicine and Metabolism Lab, Derio, Spain;(3)Hospital Universitario Central de Asturias, Gastroenterology, Asturias, Spain;(4)Hospital Universitario Marqués de Valdecilla and IDIVAL, Gastroenterology, Santander, Spain;(5)Hospital General Universitario de Alicante- CIBERehd and Instituto de Investigación Sanitaria y Biomédica de Alicante ISABIAL, Gastroenterology, Alicante, Spain;(6)Hospital Galdakao-Usansolo, Gastroenterology, Vizcaya, Spain;(7)Hospital Clínico Universitario de Valladolid, Gastroenterology, Valladolid, Spain;(8)Universitario de Gran Canaria Dr. Negrín, Gastroenterlogy, Las Palmas de Gran Canaria, Spain;(9)Hospital Universitario Reina Sofía and IMIBIC, Gastroenterology, Córdoba, Spain;(10)Hospital Universitari i Politecnic La Fe and CIBERehd, Gastroenterology, Valencia, Spain;(11)Complexo Hospitalario Universitario de Santiago, Gastroenterology, Santiago de Compostela, Spain;(12)Hospital Universitario de Fuenlabrada e Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Gastroenterology, Madrid, Spain;(13)Hospital General Universitario de Ciudad Real, Gastroenterology, Ciudad Real, Spain;(14)Hospital San Jorge, Gastroenterology, Huesca, Spain;(15)Hospital Universitari Son Espases, Gastroenterology, Palma de Mallorca, Spain;(16)Hospital Universitari Mutua Terrasa, Gastroenterology, Terrasa, Spain
DOP20: Genetic of vitamin D as predictor of response to adalimumab in Crohn’s DiseaseECCO'21 Virtual
Year: 2021
Authors: Cusato, J.(1);Ribaldone, D.G.(1);Bertani, L.(2);Antonucci, M.(1);Tomasello, C.(3);Caviglia, G.P.(1);Dibetto, S.(1);Mangia, M.(1);Astegiano, M.(4);D'Avolio, A.(1)
(1)University of Turin, Department of Medical Sciences, Turin, Italy;(2)University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy;(3)Ospedale Maria Vittoria, S.C. Farmacie Ospedaliere, Turin, Italy;(4)Molinette hospital, Unit of Gastroenterology, Turin, Italy