P061: Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytesECCO’23 CopenhagenYear: 2023
Authors: Canales-Herrerias, P.(1)*;Uzzan*, M.(1);Seki*, A.(1);Czepielewski, R.S.(2);Verstockt, B.(3);Dunn, A.(1);Dai, D.(1);Ko, H.M.(4);Furtado, G.C.(5);Tokuyama, M.(1);Tankelevich, M.(1);Meringer, H.(1);Cossarini, F.(1);Jha, D.(1);Paulsen, J.D.(6);Nakadar, M.Z.(6);Wong, J.(6);Sharma, K.(1);Rosenstein, A.(1);Dawson, T.(7);Singh, H.(1);Lim, J.(8);Lira, S.A.(5);Yajnik, V.(9);Reboldi, A.(10);Petralia, F.(11);Vermeire, S.(3);Polydorides, A.D.(6);Randolph, G.J.(2);Colombel , J.F.(1);Mehandru, S.(1);
(1)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;(2)Washington University School of Medicine, Pathology & Immunology, St. Louis, United States;(3)University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(4)Columbia University, Pathology, New York, United States;(5)Icahn School of Medicine at Mount Sinai, Immunology, New York, United States;(6)Icahn School of Medicine at Mount Sinai, Pathology- Molecular and Cell Based Medicine, New York, United States;(7)Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, United States;(8)Icahn School of Medicine at Mount Sinai, Microbiology, New York, United States;(9)Takeda Pharmaceuticals, Gastroenterology, Boston, United States;(10)UMass Chan Medical School, Pathology, Worcester, United States;(11)Icahn School of Medicine at Mount Sinai, Genetics and Genomic Sciences, New York, United States;
P062: Antibody responses to SARS-CoV-2 vaccination outperform responses induced by natural infection in patients with IBD receiving immunosuppressive medications: a report from the ICARUS-IBD consortium.ECCO’23 CopenhagenYear: 2023
Authors: González Cueto, E.(1)*;Matthew, E.(1);Wellens, J.(2,3);Martinez Pazos, V.(4);Thompson, C.(5);Klenerman, P.(1,3);Cadwell, K.(6);Colombel, J.F.(4);Satsangi, J.(3);Wong, S.Y.(4);
(1)Oxford University, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom;(2)University Hospitals Leuven- KU Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(3)Oxford University- Translational Gastro-Intestinal Unit, Nuffield Department of Medicine, Oxford, United Kingdom;(4)Icahn School of Medicine at Mount Sinai, The Henry D. Janowitz Division of Gastroenterology, New York, United States;(5)Warwick Medical School- University of Warwick, Division of Biomedical Sciences, Coventry, United Kingdom;(6)University of Pennsylvania-Perelman School of Medicine, Division of Gastroenterology- Department of Medicine, Philadelphia, United States;ICARUS-IBD consortium
P063: Host-mycobiome interactions during the resolution of inflammation in experimental colitisECCO’23 CopenhagenYear: 2023
Authors: De Salvo, C.(1)*;Wargo, H.(1);Vidmar, K.(1);Di Martino, L.(2);Mahabaleshwar, G.(1);Cominelli, F.(2);Ghannoum, M.(2);Pizarro, T.(1);
(1)Case Western Reserve University- School of Medicine, Pathology, Cleveland, United States;(2)Case Western Reserve University- School of Medicine, Digestive Health Research Institute, Cleveland, United States;
P064: High intestinal Secretory Leukocyte Protease Inhibitor (SLPI) expression correlates with abundant neutrophilic inflammation and identifies Inflammatory Bowel Disease patients with a strong IL-17 response.ECCO’23 CopenhagenYear: 2023
Authors: Nugteren, S.(1);Calado, B.(1)*;Simons-Oosterhuis, Y.(1);H. Hulleman-van Haaften, D.(1);Klomberg, R.(2);Tuk, B.(1);Charrout, M.(3);J. Lindenbergh-Kortleve, D.(1);K. Smits, W.(1);Doukas, M.(4);A. Sanders, M.(5);van Beek, G.(5);C. Escher, J.(2);de Ridder, L.(2);N. Samsom, J.(1);
(1)Erasmus University Medical Center, Department of Pediatrics- division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)Sophia Children's Hospital-Erasmus University Medical Center, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(3)Delft University of Technology, Delft Bioinformatics Lab, Delft, The Netherlands;(4)Erasmus University Medical Center, Department of Pathology, Rotterdam, The Netherlands;(5)Erasmus University Medical Center, Department of Hematology- division Bioinformatics, Rotterdam, The Netherlands;
P065: Altered B cell expansion and maturation in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Kappel-Latif, S.(1);Kotagiri, P.(2);Schuld, G.(1);Schlager, L.(1);Walterskirchen, N.(1);Schimek, V.(1);Jobst, J.(1);Murthy, S.(3);Messner, B.(4);Lyons, P.A.(2);Oehler, R.(1);Bergmann, M.(1);Stift, A.(1);Unger, L.(5)*;
(1)Medical University of Vienna, Dept. of General Surgery, Vienna, Austria;(2)University of Cambridge, Jeffrey Cheah Biomedical Center- Department of Medicine, Cambridge, United Kingdom;(3)Medical University of Vienna, Clinical Institute of Laboratory Medicine, Vienna, Austria;(4)Medical University of Vienna, Dept. of Cardiac Surgery, Vienna, Austria;(5)Medical University of Vienna, Dept. of General Surgery- Div. of Visceral Surgery, Vienna, Austria;
P066: ON104, a novel bioengineered antibody targeting oxidized Macrophage Migration Inhibitory Factor (oxMIF) shows efficacy in two distinct models of experimental colitisECCO’23 CopenhagenYear: 2023
Authors: Ferhat, M.(1)*;Mangano, K.(2);Nicoletti, F.(2);Landlinger, C.(1);Michael, T.(1);
(1)OncoOne, Research & Development GmbH, Vienna, Austria;(2)University of Catania, Department of Biomedical and Biotechnological Sciences, Catania, Italy;
P067: Fractal analysis of extracellular matrix as a new histological method for observer-independent quantification of intestinal fibrosis in Crohn's DiseaseECCO’23 CopenhagenYear: 2023
Authors: Weber, M.C.(1)*;Schmidt, K.(1);Buck, A.(1);Kasajima, A.(2);Becker, S.(3);Wilhelm, D.(1);Friess, H.(4);Neumann, P.A.(1);
(1)Klinikum rechts der Isar- Technical University of Munich, Department of Surgery, Munich, Germany;(2)Klinikum rechts der Isar- Technical University of Munich, Insitute of Pathology, Munich, Germany;(3)ETH Zurich, Department of Mathematics, Zurich, Switzerland;(4)Klinikum rechst der Isar- Technical University of Munich, Department of Surgery, Munich, Germany;
P068: Polyunsaturated fatty acid excess fuels pro-inflammatory transcriptional networks in GPX4 deficient intestinal epithelial cellsECCO’23 CopenhagenYear: 2023
Authors: Meyer, M.(1)*;Grabherr, F.(1);Schwärzler, J.(1);Mayr, L.(1);Jukic, A.(1);Rao, Z.(2);Rieder, D.(3);Zollner, A.(1);Grander, C.(1);Trajanoski, Z.(3);Koeberle, A.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;(2)University of Innsbruck, Michael Popp Research Institute, Innsbruck, Austria;(3)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;
P069: Elevated adaptive immune responses to multiple Lachnospiraceae bacterial flagellins in therapy-naïve pediatric CD patients are associated with distinct immune pathology.ECCO’23 CopenhagenYear: 2023
Authors: Barendregt, D.(1)*;Joosse, M.E.(1);Alexander, K.L.(2);Costes, L.M.M.(1);Tindemans, I.(1);Simons-Oosterhuis, Y.(1);Aardoom, M.A.(3);Klomberg, R.C.W.(3);Heredia, M.(1);Hulleman- van Haaften, D.H.(1);Tuk, B.(1);Nugteren, S.(1);Doukas, M.(4);Escher, J.C.(3);de Ridder, L.(3);Elson, C.O.(2);Samsom, J.N.(1);
(1)Erasmus University Medical Center-Sophia Children's Hospital, Laboratory of Pediatrics division Gastroenterology and Nutrition, Rotterdam, The Netherlands;(2)University of Alabama at Birmingham, Department of Medicine division of Gastroenterology and Hepatology, Birmingham AL, United States;(3)Erasmus University Medical Center-Sophia Children's Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(4)Erasmus University Medical Center, Department of Pathology, Rotterdam, The Netherlands;
P070: Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune systemECCO’23 CopenhagenYear: 2023
Authors: Olbei, M.(1)*;Modos, D.(2,3);Cozzetto, D.(1);Powell, N.(1);Korcsmaros, T.(1,2,3);
(1)Imperial College London, Division of Digestive Diseases- Department of Metabolism- Digestion and Reproduction, London, United Kingdom;(2)Quadram Institute Bioscience, Systems Biology of Gut-Microbe Interactions, Norwich, United Kingdom;(3)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;
P071: T-cell, B-cell and monocytic infiltrations of myenteric plexus in IBDECCO’23 CopenhagenYear: 2023
Authors: Wiese, J.J.(1)*;Fascì, A.(1);Kühl, A.A.(1);Atreya, R.(2);Patankar, J.(2);Siegmund, B.(1);Prüß, M.S.(1);Schumann, M.(1);
(1)Charité - Universitätsmedizin Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology- Campus Benjamin Franklin, Berlin, Germany;(2)University Hospital Erlangen, Deptartment of Internal Medicine 1- Faculty of Medicine, Erlangen, Germany;
P072: : Circadian misalignment by simulated night shifts decreases colonoid barrier integrity in Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Swanson, G.(1)*;Shaikh, M.(1);Keshavarzian, A.(1);Scheer, F.(2);
(1)Rush University Medical Center, Center of Integrated Microbiology and Chronobiology, Chicago, United States;(2)Harvard University, Division of Sleep Medicine, Boston, United States;
P073: Let´s talk about sex: an unicentric cross-sectional study on sexual dysfunction, sexual satisfaction and body schema disorders in Inflammatory Bowel DiseaseECCO’23 CopenhagenYear: 2023
Authors: Lindenthal, D.(1);Kranzeder, A.(2)*;Hirning, C.(2);von Wietersheim, J.(2);Klaus, J.(1);
(1)University Hospital Ulm, Department of Internal Medicine I, Ulm, Germany;(2)University Hospital Ulm, Department of Psychosomatic Medicine and Psychotherapy, Ulm, Germany;
P075: Characterisation and structural analysis of a new murine model to study postoperative fibrotic recurrence in Crohn's disease combining ileocecal resection with chronic colitisECCO’23 CopenhagenYear: 2023
Authors: Schmidt, K.(1)*;Li, C.(1);Buck, A.(1);Wilhelm, D.(1);Friess, H.(1);Weber, M.C.(1);Neumann, P.A.(1);
(1)Technical University of Munich- Klinikum rechts der Isar, Department of Surgery, Munich, Germany;
P076: Abdominal pain severity for IBD in remission correlates with genetic clustering and enzymatic activity of faeces-derived Candida albicans strainsECCO’23 CopenhagenYear: 2023
Authors: Van Thiel, I.(1,2)*;Maasland, T.(3);van Wassenaer, E.(4);Hoekman, D.(5);Spooren, C.(6,7);Hakvoort, T.(1,8);Admiraal, I.(1,8);Theelen, B.(2);Levin, E.(3);Benninga, M.(5);Jonkers, D.(6,7);D'Haens, G.(4);Rosendahl, S.(9);Boekhout, T.(2,10);Hagen, F.(10,11,12);de Jonge, W.(1,4,13);van den Wijngaard, R.(1,4);
(1)AmsterdamUMC- loc. AMC, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Westerdijk Fungal Biodiversity Institute, Yeast Research, Utrecht, The Netherlands;(3)Horaizon, Horaizon, Delft, The Netherlands;(4)AmsterdamUMC- loc. AMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(5)AmsterdamUMC- loc. AMC, Department of Pediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands;(6)Maastricht University Medical Centers+, Department of Internal Medicine- Division Gastroenterology-Hepatology, Maastricht, The Netherlands;(7)Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands;(8)AmsterdamUMC- loc. AMC, Microbiota Center Amsterdam, Amsterdam, The Netherlands;(9)University of Copenhagen, Department of Biology- Section for Ecology & Evolution, Copenhagen, Denmark;(10)University of Amsterdam, Institute of Biodiversity and Ecosystem Dynamics IBED, Amsterdam, The Netherlands;(11)Westerdijk Fungal Biodiversity Institute, Medical Mycology Group, Utrecht, The Netherlands;(12)University Medical Center Utrecht, Medical Microbiology, Utrecht, The Netherlands;(13)University Hospital Bonn, Department of General- Visceral- Thoracic and Vascular Surgery, Bonn, Germany;
P077: Group 1 innate lymphoid cells in creeping fat of Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Mori, R.(1)*;Ogino, T.(1,2);Sekido, Y.(1);Hata, T.(1);Hamabe, A.(1);Takahashi, H.(1);Miyoshi, N.(1);Uemura, M.(1);Mizushima, T.(1,2,3);Doki, Y.(1);Eguchi, H.(1);
(1)Osaka University, Department of Gastroenterological Surgery- Graduate School of Medicine, Suita- Osaka, Japan;(2)Osaka University, Department of Therapeutics for Inflammatory Bowel Diseases- Graduate School of Medicine, Suita- Osaka, Japan;(3)Osaka Police Hospital, Department of Gastroenterological Surgery, Osaka, Japan;
P078: Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.ECCO’23 CopenhagenYear: 2023
Authors: Walaas, G.A.(1)*;Gopalakrishnan, S.(1);Bakke, I.(1,2);Skovdahl, H.K.(1,3);Flatberg, A.(1,4);Østvik, A.E.(1,5);Sandvik, A.K.(1,3,5);Bruland, T.(1,5);
(1)Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway;(2)St. Olav's University Hospital, Clinic of Laboratory Medicine, Trondheim, Norway;(3)Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, Trondheim, Norway;(4)St. Olav's University Hospital, Central Administration, Trondheim, Norway;(5)St. Olav's University Hospital, Department of Gastroenterology and Hepatology, Trondheim, Norway;
P079: Attenuation of inflammation and histologic production-dependent improvement by engineered high acetate producing Saccharomyces boulardii in DSS-induced colitisECCO’23 CopenhagenYear: 2023
Authors: Deleu, S.(1)*;Trindade de Carvalho , B.(2);Jacobs, I.(3);Arnauts, K.(1);Deprez, L.(4);Vissers , E.(1);Lenfant, M.(1);De Hertogh, G.(5);Huys, G.(6);Thevelein, J.(2);Raes, J.(6);Vermeire, S.(7);
(1)KU Leuven, Department of Chronic Diseases- Metabolism & Ageing CHROMETA, Leuven, Belgium;(2)Bio-incubator, Novelyeast, Leuven, Belgium;(3)KU Leuven, Department of Microbiology- Immunology and Transplantation- Allergy and Clinical Immunology Research Group, Leuven, Belgium;(4)KULeuven, Department of Chronic Diseases- Metabolism & Ageing CHROMETA, Leuven, Belgium;(5)University hospitals Leuven, Laboratory of Morphology and Molecular Pathology, Leuven, Belgium;(6)KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium;(7)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;MIMOSA
P080: Mucosal clock and inflammation regulatory genes are disrupted in treatment naïve pediatric patients with ulcerative colitisECCO’23 CopenhagenYear: 2023
Authors: Labes, S.(1);Tabach, Y.(1);Matar, M.(2,3);Shamir, R.(2,3);Shouval, D.S.(2,3);Froy, O.(4);Weintraub, Y.(2,3)*;
(1)Hebrew University of Jerusalem, Department of Developmental Biology and Cancer Research- Institute for Medical Research Israel-Canada, Jerusalem, Israel;(2)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petach Tikva, Israel;(3)Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel;(4)The Hebrew University, Institute of Biochemistry- Food Science and Nutrition- the Robert H Smith Faculty of Agriculture- Food and Environment-, Rehovot, Israel;
