University Hospital Tübingen, Internal Medicine I, Tübingen, Germany

¹UiT, The Arctic University of Norway, Department of Health and Care Sciences, Harstad, Norway, ²Østfold University College, Fredrikstad, Norway, Fredrikstad, Norway, ³Østfold Hospital Trust, Department of Gastroenterology, Kalnes, Norway, ⁴University Hospital of North Norway, UNN, Tromsø, Norway, ⁵UiT, The Arctic University of Norway, Department of Health and Care Sciences, Harstad, Norway, Harstad, Norway, ⁶University Hospital of North Norway, Harstad, Norway, ⁷UiT, The Arctic University of Norway, Harstad, Norway

¹Royal Wolverhampton NHS Trust, Gastroenterology Unit, Wolverhampton, UK, ²Royal Wolverhampton NHS Trust, Clinical Biochemistry Unit, Wolverhampton, UK

Institute of Clinical and Experimental Medicine, Hepatogastroenterology, Prague, Czech Republic

¹Hyogo College of Medicine, Inflammatory Bowel Disease, Nishinomiya, Japan, ²Hyogo College of Medicine, Intestinal Inflammation Research, Nishinomiya, Japan

¹John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, UK, ²Mathematical Institute, Oxford, UK, ³Big Data Institute, Oxford, UK, ⁴University of Oxford, Psychiatry Department, Oxford, UK, ⁵University of Oxford, Nuffield Department of Population Health, Oxford, UK, ⁶University of Oxford, Centre for Statistics in Medicine, Oxford, UK

¹University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, ²UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the Host, Clermont-Ferrand, France, ³University Hospital G. Montpied, Biochemistry Laboratory, Clermont-Ferrand, France, ⁴University Hospital, Rennes, France, ⁵Hospital of Bayonne, Gastroenterology Department, Bayonne, France, ⁶University Hospital, Biostatistics Unit, DRCI Clermont-Ferrand, France

Burton Hospitals NHS Foundation Trust, Colorectal Surgery, Burton On Trent, UK

¹Center for Advanced IBD Research and Treatment, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan, ²Takeda Pharmaceutical Company Limited, Tokyo, Japan, ³Milliman, Inc., Tokyo, Japan

¹Grenoble Alpes University Hospital, University Clinic of Hepato-Gastroenterology, Grenoble, France, ²Grenoble Alpes University Hospital, Colorectal Unit Department of Surgery, Grenoble, France, ³Grenoble Alpes University Hospital, Department of Pharmacy, Grenoble, France, ⁴CHU Grenoble Alpes, University Clinic of Hepato-Gastroenterology, Grenoble, France

Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea

¹St Mark’s Academic Institute, Robin Phillip’s Fistula Research Unit, London, UK, ²St Mark’s Hospital, Department of IBD, London, UK, ³St Mark’s Hospital, Department of Surgery, London, UK, ⁴St Mark’s Academic Institute, London, UK, ⁵LNWH ST MARKS HOSPITAL, Harrow, UK

Kliniken Essen Mitte, Gastroenterology, Essen, Germany

¹Austin Health, Department of Gastroenterology, Melbourne, Australia, ²University of Melbourne, Austin Academic Centre, Melbourne, Australia, ³St. Vincent's Hospital, Department of Gastroenterology, Melbourne, Australia, ⁴Austin Health, Gastroenterology, Melbourne, Australia, ⁵Australian Catholic University, Melbourne, Australia, ⁶Austin Health, Pathology, Melbourne, Australia, ⁷Eastern Health, Gastroenterology, Melbourne, Australia, ⁸Alfred Health, Gastroenterology, Melbourne, Australia, ⁹University of Melbourne, Medicine, Melbourne, Australia

¹Oregon Health and Science University, Portland, OR, USA, ²Cedars-Sinai Medical Center, Division of Gastroenterology, Department of Medicine, Los Angeles, CA, USA, ³University Hospitals Leuven, Department of Gastroenterology, Leuven, Belgium, ⁴University of North Carolina, Center for Gastrointestinal Biology and Disease, Chapel Hill, NC, USA, ⁵Pfizer Inc., Collegeville, PA, USA

¹University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland, ²University of Lausanne, IUMSP, Lausanne, Switzerland, ³Klinik Hirslanden, Department of Gastroenterology, Zurich, Switzerland, ⁴University of Bern, Institute of Social and Preventive Medicine, Bern, Switzerland, ⁵CHUV - Centre Hospitalier Universitaire Vaudois, Department of Gastroenterology, Lausanne, Switzerland, ⁶ Center of Gastroenterology and Hepatology, Zurich, Switzerland, ⁷University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

¹Division of Internal Medicine, “'Villa Sofia-Cervello” Hospital, Palermo, Italy, ²Gastroenterology Unit, A.O.O.R. “S. Elia- M. Raimondi”, Caltanissetta, Italy

¹Shaare Zedek Medical Center, Institute of Pediatric Gastroenterology, Jerusalem, Israel, ²The Broad Institute of MIT and Harvard, Cambridge, Center for Computational and Integrative Biology, Mass. General Hospital, Boston, USA, ³Soroka Medical Center, Beer Sheva, Israel, ⁴SickKids, Toronto, Canada, ⁵Sapienza University of Rome, Rome, Italy, ⁶CHOP, Philadelphia, USA, ⁷Children’s Hospital, Helsinki University, Helsinki, Finland, ⁸Schneider's Children Hospital, Petach Tiqva, Israel, ⁹Wolfson Medical Center, Holon, Israel

¹Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, ²University of British Columbia, Division of Gastroenterology, Department of Medicine, Vancouver, BC, Canada, ³Icahn School of Medicine at Mount Sinai Hospital, Division of Gastroenterology, New York, NY, USA, ⁴Pfizer Inc., Collegeville, PA, USA

¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Internal Medicine, Seoul, South Korea, ²Hanyang University Guri Hospital, Guri, South Korea, ³Wonkwang University, Department of Internal Medicine, Jeonbuk, South Korea, ⁴Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, ⁵Haeundae Paik Hospital, Inje University College of Medicine, Department of Internal Medicine and Gastroenterology, Busan, South Korea