OP40: PRA023 Demonstrated Efficacy and Favorable Safety as Induction Therapy for Moderately to Severely Active UC: Phase 2 ARTEMIS-UC Study ResultsECCO’23 CopenhagenYear: 2023
Authors: B. Sands*(1), L. Peyrin-Biroulet(2), S. Danese(3), D.T. Rubin(4), S. Vermeire(5), O. Laurent(6), A. Luo(6), D. Nguyen(6), JD. Lu(6),A. Wiechowska-Kozlowska(7), J. Leszczyszyn(8), R. Kempinski(9), J. Kierkus(10), C. Ma(11), T. Ritter*(12), B.G. Feagan(13), S. Targan*(14)
(1)Icahn School of Medicine at Mount Sinai, New York, New York, USA, (2)Last Inserm U954 and CHU de Nancy, Lorraine University, Nancy, France, (3)Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Italy, (4)University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL, USA, (5)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, (6)Prometheus Biosciences, Inc., San Diego, CA, USA, (7)Endoscopy Unit, SONOMED Medical Center, Szczecin, Poland, (8)Department of Gastroenterology, Melita Medical, Wroclaw, Poland, (9)Wroclaw Medical University, Department of Gastroenterology and Hepatology, Wroclaw, Poland, (10)Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland, (11)Alimentiv Inc., London, ON, Canada Division of Gastroenterology & Hepatology, Department of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada, (12)GI Alliance, Southlake, Texas, USA, (13)Department of Medicine, Division of Gastroenterology, Western University, London, ON, Canada, (14)Division of Gastroenterology and Hepatology, Center for Inflammatory Bowel Diseases, Cedars-Sinai Medical Center, Los Angeles, CA,USA
P001: Obefazimod upregulates miR-124 and downregulates the expression of some cytokines in blood and rectal biopsies of patients with moderate-to-severe ulcerative colitis.ECCO’23 CopenhagenYear: 2023
Authors: Santo, J.(1)*;Gineste, P.(1);Scherrer, D.(2);Nitcheu, J.(1);Ehrlich, H.(3);Sands, B.E.(4);Vermeire, S.(5);
(1)Abivax, Clinical Operations, Paris, France;(2)Abivax, Research and Development, Paris, France;(3)Abivax, Chief Executive Officer, Paris, France;(4)Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States;(5)UZ Leuven, Department of Gastroenterology & Hepatology, Leuven, Belgium;
P002: Exclusive Enteral Nutrition, the gut microbiome and corticosteroid response in patients with acute severe colitisECCO’23 CopenhagenYear: 2023
Authors: Bajaj, A.(1)*;Markandey, M.(1);Vuyyuru, S.(1);Mohta, S.(1);Singh, M.(1);Verma, M.(1);Kumar, S.(1);Kante, B.(1);Kumar, P.(1);Makharia, G.(1);Kedia, S.(1);Travis, S.(2);Ahuja, V.(1);
(1)All India Institute of Medical Sciences, Department of Gastroenterology, New Delhi, India;(2)University of Oxford, The Kennedy Institute and Translational Gastroenterology Unit, Oxford OX2 7FY, United Kingdom;
P003: MicroRNAs as biomarkers in Inflammatory Bowel Disease unclassified (IBDU) patient samples may predict the development from IBDU to Crohn's Disease or Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Pallikkunnath James, J.(1)*;Riis, L.B.(1,2);Malham, M.(3,4);Høgdall, E.(1,2);Langholz, E.(2,5);Nielsen, B.S.(6);
(1)Herlev University Hospital, Department of Pathology, Herlev, Denmark;(2)University of Copenhagen, Institute for Clinical Medicine, Copenhagen, Denmark;(3)Copenhagen University Hospital - Amager and Hvidovre, The Pediatric Department, Hvidovre, Denmark;(4)University of Copenhagen, Copenhagen Center for Inflammatory Bowel Disease in Children- Adolescents and Adults- Hvidovre Hospital, Hvidovre, Denmark;(5)Herlev University Hospital, Department of Gasteroenterology, Herlev, Denmark;(6)Bioneer A/S, Molecular Histology, Hørsholm, Denmark;
P004: Untargeted serum metabolome shows Crohn Disease (CD) associated signature, signals that correlate with disease activity and CRP, and signals that may precede disease flareECCO’23 CopenhagenYear: 2023
Authors: Levhar, N.(1)*;Hadar, R.(1);Braun, T.(1);Efroni, G.(1);Abramovich, I.(2);Gottlieb, E.(2);Granot, M.(1);Sandra, N.(3);Selinger, L.(3);Picard, O.(3);Yavzori, M.(3);Lahat, A.(3);Eliakim, R.(3);Weiss, B.(1);Kopylov, U.(3);Ben-Horin, S.(3);Amir, A.(1);Haberman Ziv, Y.(1);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)Technion Institute, The Ruth and Bruce Rappaport- Faculty of Medicine, Haifa, Israel;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;
P005: Molecular-based classification of ulcerative colitis and its dynamicECCO’23 CopenhagenYear: 2023
Authors: Seyed Tabib, N.S.(1)*;Verstockt, S.(1);Verstockt, B.(1,2);Ferrante, M.(1,2);Sabino, J.(1,2);Vermeire, S.(1,2);
(1)KU Leuven, Department of Clinical and Experimental Medicine CHROMETA- Translational Research in GastroIntestinal Disorders TARGID, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;
P006: Engineered propionate-producing bacteria attenuates murine colitis by modulating the immune function of resident macrophages via histone deacetylaseECCO’23 CopenhagenYear: 2023
Authors: Feng, Z.(1)*;Wang, X.(1);Kang, G.(2);Zhao, J.(1);Ye, Y.(1);Liu, L.(1);Huang, H.(2);Cao, X.(1);
(1)Tianjin Medical University General Hospital, Department of Gastroenterology and Hepatology, Tianjin, China;(2)Tianjin University, Department of Biochemical Engineering- School of Chemical Engineering and Technology, Tianjin, China;
P007: Paradoxical effects of high and low emulsifier diets on intestinal permeability in unstressed and stressed states in healthy human adults: a pilot randomised controlled feeding trial.ECCO’23 CopenhagenYear: 2023
Authors: Fitzpatrick, J.(1)*;Gibson, P.R.(1);Taylor, K.M.(2);Halmos, E.P.(1);
(1)Monash University, Department of Gastroenterology, Melbourne, Australia;(2)Alfred Health, Department of Gastroenterology, Melbourne, Australia;
P008: Fibrostricturing Crohn's disease is characterised by an imbalance in active eosinophils, Th1, Th2 and regulatory T cellsECCO’23 CopenhagenYear: 2023
Authors: Jacobs, I.(1)*;Ke, B.J.(2);Cremer, J.(1,2);D'Hoore, A.(3);Bislenghi, G.(3);Matteoli, G.(2);De Hertogh, G.(4);Sabino, J.(2,3);Ferrante, M.(2,3);Vermeire, S.(2,3);Breynaert, C.(1,5);Vanuytsel, T.(2,3);Verstockt, B.(2,3);
(1)KU Leuven, Department of Microbiology- Immunology and transplantation, Leuven, Belgium;(2)KU Leuven, Department of Chronic Diseases and Metabolism, Leuven, Belgium;(3)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)KU Leuven, Department of Imaging and Pathology, Leuven, Belgium;(5)University Hospitals Leuven, Department of General Internal Medicine, Leuven, Belgium;
P009: IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cellsECCO’23 CopenhagenYear: 2023
Authors: Ullrich, K.(1)*;Derdau, J.(1);Baltes, C.(2);Rosso, G.(3);Uderhardt, S.(4);Schulze, L.L.(1);Liu, L.J.(1);Dedden, M.(1);Spocinska, M.(1);Kainka, L.(2);Kubánková, M.(3);Müller, T.M.(1);Schmidt, N.M.(1);Becker, E.(1);Atreya, I.(1);Neurath-Finotto, S.(5);Prots, I.(6);Weigmann, B.(1);López-Posadas, R.(1);Atreya, R.(1);Ekici, A.B.(7);Lautenschläger, F.(8);Guck, J.(3);Neurath, M.F.(1);Zundler, S.(1);
(1)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(2)Saarland University, Experimental Physics, Saarbrücken, Germany;(3)Max Planck Institute for the Science of Light, Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany;(4)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine 3, Erlangen, Germany;(5)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Molecular Pneumology, Erlangen, Germany;(6)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Stem Cell Biology, Erlangen, Germany;(7)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute of Human Genetics, Erlangen, Germany;(8)Saarland University, Experimental Physics- Center for Biophysics, Saarbrücken, Germany;
P011: Patient-derived organoids as an epithelial model for preclinical IBD research and drug development.ECCO’23 CopenhagenYear: 2023
Authors: Frias, J.(1);Derksen, M.(1);Verissimo, C.S.(1);van Dooremalen, W.T.M.(1);Oldenburg, B.(2);Vries, R.G.J.(1);Boj, S.F.(1);Pourfarzad, F.(1);Pott, J.(1)*;
(1)HUB Organoids, Research and Development, Utrecht, The Netherlands;(2)University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands;
P012: The administration of mm-miR-378a-3p exacerbates chronic inflammation and fibrosis in a murine intestinal modelECCO’23 CopenhagenYear: 2023
Authors: Seco-Cervera, M.(1)*;Argilés-Arberola, D.(2);Bauset, C.(2);Lis-López, L.(1);Coll, S.(2);Cosín-Roger, J.(1);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO- Valencia- Spain., Dept. Pharmacology. School of Medicine and Dentistry. University of Valencia, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P013: Role of IL-36RA mutations in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Hecker, J.(1)*;Saurenbach, J.(1);Letizia, M.(1);Löscher , B.S.(2);Franke, A.(2);Kühl, A.A.(3);Atreya, R.(4);Koop, K.(4);Neufert, C.(4);Trajanoski , Z.(5);Schütz, A.(6);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité- Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;(3)Charité- Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin- iPATH.Berlin- Campus Benjamin Franklin, Berlin, Germany;(4)University Hospital Erlangen- Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(5)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;(6)Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft MDC, Berlin- Germany, Berlin, Germany;
P014: Behaviour in mice with chronic DSS colitis mimics fatigue in IBD and is associated with neuroinflammationECCO’23 CopenhagenYear: 2023
Authors: Truyens, M.(1,2,3)*;Lernout, H.(1,2);Vandendriessche, C.(2,4,5);Bruggeman, A.(2,5,6);Xie, J.(2,4,5);De Vos, M.(1);Vermeirssen, V.(5,7,8);Vandenbroucke, R.(2,4,5);Laukens, D.(1,2,4);
(1)Ghent University, Department of Internal Medicine and Paediatrics, Ghent, Belgium;(2)Ghent University, VIB Centre for Inflammation Research IRC, Ghent, Belgium;(3)University Hospital Ghent, Department of Gastroenterology, Ghent, Belgium;(4)Ghent University, Ghent Gut Inflammation Group GGIG, Ghent, Belgium;(5)Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium;(6)Ghent University Hospital, Department of Neurology, Ghent, Belgium;(7)Cancer Research Institute Ghent CRIG, Lab for Computational Biology- Integromics and Gene Regulation CBIGR, Ghent, Belgium;(8)Ghent University, Department of Biomolecular Medicine, Ghent, Belgium;
P015: CITE-seq analysis revealed immune cell diversity in colonic mesenteric lymph nodes from IBD patientsECCO’23 CopenhagenYear: 2023
Authors: Wils, P.(1)*;Mehta, H.(2);rubio, M.(2);Sarfati, M.(2);Chapuy, L.(3);
(1)Claude Huriez Hospital- University of Lille 2, Hepato-Gastroenterology Department, Lille, France;(2)Centre de Recherche du Centre Hospitalier de l'Université de Montréal CRCHUM- University of Montreal, Immunoregulation Laboratory- Immunopathology Department, Montreal, Canada;(3)Montreal Children's Hospital- Research Institute of the McGill University Health Centre RI-MUHC- McGill University- Montreal- Qc- Canada, Department of Pediatrics, Montreal, Canada;
P016: Dietary supplementation with Brazilian jaboticaba-sabará fruit (Myrciaria jaboticaba (Vell.) O. Berg) ameliorates colitis-driven colorectal cancer in miceECCO’23 CopenhagenYear: 2023
Authors: Nascimento, R.D.P.D.(1)*;Rizzato, J.S.(1);Polezi, G.(1);Moya, A.M.T.M.(1);Silva, M.F.(2);Franchi Junior, G.C.(3);Borguini, R.G.(4);Santiago, M.C.P.D.A.(4);Paiotti, A.P.R.(5);Pereira, J.A.(6);Martinez, C.A.R.(6);Marostica Junior, M.R.(1);
(1)University of Campinas, Food Science and Nutrition, Campinas, Brazil;(2)Federal University of São Paulo, Biological Sciences, Diadema, Brazil;(3)University of Campinas, Medical Sciences, Campinas, Brazil;(4)Brazilian Agricultural Research Corporation, Embrapa Food Technology, Rio de Janeiro, Brazil;(5)Federal University of São Paulo, Medicine, São Paulo, Brazil;(6)São Francisco University, Postgraduate Program in Health Sciences, Bragança Paulista, Brazil;Laboratory of Nutrition and Metabolism
P017: Fecal wash host transcriptomics identifies inflammation throughout the colon and terminal ileumECCO’23 CopenhagenYear: 2023
Authors: Dan, S.(1);Ungar, B.(2)*;Ben-Moshe, S.(1);Bahar Halpern, K.(1);Yavzori, M.(2);Fudim, E.(2);Picard, O.(2);Abitbol, C.M.(2);Harnik, S.(2);Kopylov, U.(2);Ben-Horin, S.(2);Itzkovitz, S.(1);
(1)Weizmann Institute of Science, mcb, Rehovot, Israel;(2)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;Equal contribution
P018: Expression of annexin A1 and NLRP3 inflamassome in Chron's diseaseECCO’23 CopenhagenYear: 2023
Authors: Koga Ito, H.T.(1)*;Lice , I.(1);R. S. Sasso, G.(2);Artigiani, R.(3);D. Gil, C.(2);
(1)Federal University of São Paulo - UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(2)Federal University of Sao Paulo – UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(3)Federal University of Sao Paulo – UNIFESP, Department of Pathology, São Paulo, Brazil;
P019: Host-Enterobacteriaceae interactions and mitochondrial dysfunction in Crohn's colitisECCO’23 CopenhagenYear: 2023
Authors: Holani, R.(1)*;Bar-Yoseph, H.(2);Krekhno, Z.(3);Moon, K.M.(4);Stacey, R.G.(4);Serapio-Palacios, A.(3);Bressler, B.(5);Donald, K.(6);Foster, L.J.(7);Finlay, B.B.(3);
(1)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver- British Columbia, Canada;(2)Rambam Health Care Campus, Gastroenterology, Haifa, Israel;(3)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver, Canada;(4)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vancouver, Canada;(5)University of British Columbia, Division of Gastroenterology, Vancouver, Canada;(6)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunolgy, Vancouver, Canada;(7)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vanocuver, Canada;
P020: Characterisation of mucus in patients with Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Kramer, C.(1)*;Ziegler, J.(1);Alzain, N.(1);Schroeter, S.(1);Almalla, A.(2);Elomaa, L.(2);Addante, A.(3);Kuppe, A.(3);Fentker, K.(4);Nazat Martinez Medina, J.(5);Jarquin-Diaz, V.H.(5);Rulff, H.(6);Gradzielski, M.(6);Forslund, S.(5);Mertins, P.(4);Mall, M.(3);Weinhart, M.(2);Glauben, R.(1);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin, Medical Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany;(3)Charité - Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine- Immunology and Critical Care Medicine, Berlin, Germany;(4)Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Berlin Institute of Health, Proteomics, Berlin, Germany;(5)Max Delbrück Center for Molecular Medicine and Charité University Hospital, Forslund group, Berlin, Germany;(6)Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Berlin, Germany;
