P004: Untargeted serum metabolome shows Crohn Disease (CD) associated signature, signals that correlate with disease activity and CRP, and signals that may precede disease flareECCO’23 CopenhagenYear: 2023
Authors: Levhar, N.(1)*;Hadar, R.(1);Braun, T.(1);Efroni, G.(1);Abramovich, I.(2);Gottlieb, E.(2);Granot, M.(1);Sandra, N.(3);Selinger, L.(3);Picard, O.(3);Yavzori, M.(3);Lahat, A.(3);Eliakim, R.(3);Weiss, B.(1);Kopylov, U.(3);Ben-Horin, S.(3);Amir, A.(1);Haberman Ziv, Y.(1);
(1)Sheba Medical Center, Pediatric Gastroenterology, Ramat Gan, Israel;(2)Technion Institute, The Ruth and Bruce Rappaport- Faculty of Medicine, Haifa, Israel;(3)Sheba Medical Center, Gastroenterology, Ramat Gan, Israel;
P005: Molecular-based classification of ulcerative colitis and its dynamicECCO’23 CopenhagenYear: 2023
Authors: Seyed Tabib, N.S.(1)*;Verstockt, S.(1);Verstockt, B.(1,2);Ferrante, M.(1,2);Sabino, J.(1,2);Vermeire, S.(1,2);
(1)KU Leuven, Department of Clinical and Experimental Medicine CHROMETA- Translational Research in GastroIntestinal Disorders TARGID, Leuven, Belgium;(2)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;
P006: Engineered propionate-producing bacteria attenuates murine colitis by modulating the immune function of resident macrophages via histone deacetylaseECCO’23 CopenhagenYear: 2023
Authors: Feng, Z.(1)*;Wang, X.(1);Kang, G.(2);Zhao, J.(1);Ye, Y.(1);Liu, L.(1);Huang, H.(2);Cao, X.(1);
(1)Tianjin Medical University General Hospital, Department of Gastroenterology and Hepatology, Tianjin, China;(2)Tianjin University, Department of Biochemical Engineering- School of Chemical Engineering and Technology, Tianjin, China;
P007: Paradoxical effects of high and low emulsifier diets on intestinal permeability in unstressed and stressed states in healthy human adults: a pilot randomised controlled feeding trial.ECCO’23 CopenhagenYear: 2023
Authors: Fitzpatrick, J.(1)*;Gibson, P.R.(1);Taylor, K.M.(2);Halmos, E.P.(1);
(1)Monash University, Department of Gastroenterology, Melbourne, Australia;(2)Alfred Health, Department of Gastroenterology, Melbourne, Australia;
P008: Fibrostricturing Crohn's disease is characterised by an imbalance in active eosinophils, Th1, Th2 and regulatory T cellsECCO’23 CopenhagenYear: 2023
Authors: Jacobs, I.(1)*;Ke, B.J.(2);Cremer, J.(1,2);D'Hoore, A.(3);Bislenghi, G.(3);Matteoli, G.(2);De Hertogh, G.(4);Sabino, J.(2,3);Ferrante, M.(2,3);Vermeire, S.(2,3);Breynaert, C.(1,5);Vanuytsel, T.(2,3);Verstockt, B.(2,3);
(1)KU Leuven, Department of Microbiology- Immunology and transplantation, Leuven, Belgium;(2)KU Leuven, Department of Chronic Diseases and Metabolism, Leuven, Belgium;(3)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)KU Leuven, Department of Imaging and Pathology, Leuven, Belgium;(5)University Hospitals Leuven, Department of General Internal Medicine, Leuven, Belgium;
P009: IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cellsECCO’23 CopenhagenYear: 2023
Authors: Ullrich, K.(1)*;Derdau, J.(1);Baltes, C.(2);Rosso, G.(3);Uderhardt, S.(4);Schulze, L.L.(1);Liu, L.J.(1);Dedden, M.(1);Spocinska, M.(1);Kainka, L.(2);Kubánková, M.(3);Müller, T.M.(1);Schmidt, N.M.(1);Becker, E.(1);Atreya, I.(1);Neurath-Finotto, S.(5);Prots, I.(6);Weigmann, B.(1);López-Posadas, R.(1);Atreya, R.(1);Ekici, A.B.(7);Lautenschläger, F.(8);Guck, J.(3);Neurath, M.F.(1);Zundler, S.(1);
(1)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(2)Saarland University, Experimental Physics, Saarbrücken, Germany;(3)Max Planck Institute for the Science of Light, Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany;(4)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine 3, Erlangen, Germany;(5)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Molecular Pneumology, Erlangen, Germany;(6)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Stem Cell Biology, Erlangen, Germany;(7)University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute of Human Genetics, Erlangen, Germany;(8)Saarland University, Experimental Physics- Center for Biophysics, Saarbrücken, Germany;
P011: Patient-derived organoids as an epithelial model for preclinical IBD research and drug development.ECCO’23 CopenhagenYear: 2023
Authors: Frias, J.(1);Derksen, M.(1);Verissimo, C.S.(1);van Dooremalen, W.T.M.(1);Oldenburg, B.(2);Vries, R.G.J.(1);Boj, S.F.(1);Pourfarzad, F.(1);Pott, J.(1)*;
(1)HUB Organoids, Research and Development, Utrecht, The Netherlands;(2)University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands;
P012: The administration of mm-miR-378a-3p exacerbates chronic inflammation and fibrosis in a murine intestinal modelECCO’23 CopenhagenYear: 2023
Authors: Seco-Cervera, M.(1)*;Argilés-Arberola, D.(2);Bauset, C.(2);Lis-López, L.(1);Coll, S.(2);Cosín-Roger, J.(1);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO- Valencia- Spain., Dept. Pharmacology. School of Medicine and Dentistry. University of Valencia, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P013: Role of IL-36RA mutations in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Hecker, J.(1)*;Saurenbach, J.(1);Letizia, M.(1);Löscher , B.S.(2);Franke, A.(2);Kühl, A.A.(3);Atreya, R.(4);Koop, K.(4);Neufert, C.(4);Trajanoski , Z.(5);Schütz, A.(6);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité- Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;(3)Charité- Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin- iPATH.Berlin- Campus Benjamin Franklin, Berlin, Germany;(4)University Hospital Erlangen- Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(5)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;(6)Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft MDC, Berlin- Germany, Berlin, Germany;
P014: Behaviour in mice with chronic DSS colitis mimics fatigue in IBD and is associated with neuroinflammationECCO’23 CopenhagenYear: 2023
Authors: Truyens, M.(1,2,3)*;Lernout, H.(1,2);Vandendriessche, C.(2,4,5);Bruggeman, A.(2,5,6);Xie, J.(2,4,5);De Vos, M.(1);Vermeirssen, V.(5,7,8);Vandenbroucke, R.(2,4,5);Laukens, D.(1,2,4);
(1)Ghent University, Department of Internal Medicine and Paediatrics, Ghent, Belgium;(2)Ghent University, VIB Centre for Inflammation Research IRC, Ghent, Belgium;(3)University Hospital Ghent, Department of Gastroenterology, Ghent, Belgium;(4)Ghent University, Ghent Gut Inflammation Group GGIG, Ghent, Belgium;(5)Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium;(6)Ghent University Hospital, Department of Neurology, Ghent, Belgium;(7)Cancer Research Institute Ghent CRIG, Lab for Computational Biology- Integromics and Gene Regulation CBIGR, Ghent, Belgium;(8)Ghent University, Department of Biomolecular Medicine, Ghent, Belgium;
P015: CITE-seq analysis revealed immune cell diversity in colonic mesenteric lymph nodes from IBD patientsECCO’23 CopenhagenYear: 2023
Authors: Wils, P.(1)*;Mehta, H.(2);rubio, M.(2);Sarfati, M.(2);Chapuy, L.(3);
(1)Claude Huriez Hospital- University of Lille 2, Hepato-Gastroenterology Department, Lille, France;(2)Centre de Recherche du Centre Hospitalier de l'Université de Montréal CRCHUM- University of Montreal, Immunoregulation Laboratory- Immunopathology Department, Montreal, Canada;(3)Montreal Children's Hospital- Research Institute of the McGill University Health Centre RI-MUHC- McGill University- Montreal- Qc- Canada, Department of Pediatrics, Montreal, Canada;
P016: Dietary supplementation with Brazilian jaboticaba-sabará fruit (Myrciaria jaboticaba (Vell.) O. Berg) ameliorates colitis-driven colorectal cancer in miceECCO’23 CopenhagenYear: 2023
Authors: Nascimento, R.D.P.D.(1)*;Rizzato, J.S.(1);Polezi, G.(1);Moya, A.M.T.M.(1);Silva, M.F.(2);Franchi Junior, G.C.(3);Borguini, R.G.(4);Santiago, M.C.P.D.A.(4);Paiotti, A.P.R.(5);Pereira, J.A.(6);Martinez, C.A.R.(6);Marostica Junior, M.R.(1);
(1)University of Campinas, Food Science and Nutrition, Campinas, Brazil;(2)Federal University of São Paulo, Biological Sciences, Diadema, Brazil;(3)University of Campinas, Medical Sciences, Campinas, Brazil;(4)Brazilian Agricultural Research Corporation, Embrapa Food Technology, Rio de Janeiro, Brazil;(5)Federal University of São Paulo, Medicine, São Paulo, Brazil;(6)São Francisco University, Postgraduate Program in Health Sciences, Bragança Paulista, Brazil;Laboratory of Nutrition and Metabolism
P017: Fecal wash host transcriptomics identifies inflammation throughout the colon and terminal ileumECCO’23 CopenhagenYear: 2023
Authors: Dan, S.(1);Ungar, B.(2)*;Ben-Moshe, S.(1);Bahar Halpern, K.(1);Yavzori, M.(2);Fudim, E.(2);Picard, O.(2);Abitbol, C.M.(2);Harnik, S.(2);Kopylov, U.(2);Ben-Horin, S.(2);Itzkovitz, S.(1);
(1)Weizmann Institute of Science, mcb, Rehovot, Israel;(2)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;Equal contribution
P018: Expression of annexin A1 and NLRP3 inflamassome in Chron's diseaseECCO’23 CopenhagenYear: 2023
Authors: Koga Ito, H.T.(1)*;Lice , I.(1);R. S. Sasso, G.(2);Artigiani, R.(3);D. Gil, C.(2);
(1)Federal University of São Paulo - UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(2)Federal University of Sao Paulo – UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(3)Federal University of Sao Paulo – UNIFESP, Department of Pathology, São Paulo, Brazil;
P019: Host-Enterobacteriaceae interactions and mitochondrial dysfunction in Crohn's colitisECCO’23 CopenhagenYear: 2023
Authors: Holani, R.(1)*;Bar-Yoseph, H.(2);Krekhno, Z.(3);Moon, K.M.(4);Stacey, R.G.(4);Serapio-Palacios, A.(3);Bressler, B.(5);Donald, K.(6);Foster, L.J.(7);Finlay, B.B.(3);
(1)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver- British Columbia, Canada;(2)Rambam Health Care Campus, Gastroenterology, Haifa, Israel;(3)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver, Canada;(4)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vancouver, Canada;(5)University of British Columbia, Division of Gastroenterology, Vancouver, Canada;(6)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunolgy, Vancouver, Canada;(7)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vanocuver, Canada;
P020: Characterisation of mucus in patients with Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Kramer, C.(1)*;Ziegler, J.(1);Alzain, N.(1);Schroeter, S.(1);Almalla, A.(2);Elomaa, L.(2);Addante, A.(3);Kuppe, A.(3);Fentker, K.(4);Nazat Martinez Medina, J.(5);Jarquin-Diaz, V.H.(5);Rulff, H.(6);Gradzielski, M.(6);Forslund, S.(5);Mertins, P.(4);Mall, M.(3);Weinhart, M.(2);Glauben, R.(1);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin, Medical Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany;(3)Charité - Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine- Immunology and Critical Care Medicine, Berlin, Germany;(4)Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Berlin Institute of Health, Proteomics, Berlin, Germany;(5)Max Delbrück Center for Molecular Medicine and Charité University Hospital, Forslund group, Berlin, Germany;(6)Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Berlin, Germany;
P021: Microbial metabolite receptors as mediators of pathogenic processes in Inflammatory Bowel Disease.ECCO’23 CopenhagenYear: 2023
Authors: Spathakis, M.(1,2)*;Dovrolis, N.(1,2);Tarapatzi, G.(1,2);Filidou , E.(1,2);Kandilogiannakis, L.(1,2);Valatas, V.(1,3);Drygiannakis, I.(3);Manolopoulos, V.G.(1,2);Kolios, G.(1,2);Arvanitidis, K.(1,2);Vradelis, S.(4);
(1)Democritus University of Thrace, Laboratory of Pharmacology- Department of Medicine, Alexandroupolis, Greece;(2)Democritus University of Thrace, Individualised Medicine & Pharmacological Research Solutions Center IMPReS, Alexandroupolis, Greece;(3)University of Crete, Gastroenterology and Hepatology Research Laboratory- Department of Medicine, Heraklion, Greece;(4)Democritus University of Thrace, Department of Internal Medicine- Department of Medicine, Alexandroupolis, Greece;
P023: Immune-metabolic profiles of creeping fat in relation to degree of severity in Crohn's disease postsurgical recurrence.ECCO’23 CopenhagenYear: 2023
Authors: Suau, R.(1,2)*;Pardina, E.(3);López-Tejero, M.D.(3);Lorén, V.(1,2);Zabana, Y.(2,4);Llaves, M.(1);Cordobilla, B.(3);Cañete, F.(2,5);Guasch, M.(6);Ricart-Jané, D.(3);Mañosa, M.(2,5);Domènech, E.(2,5);Domingo, J.C.(3);Manyé, J.(1,2);
(1)Institut d'Investigació Germans Trias i Pujol IGTP, IBD Research Group, Badalona, Spain;(2)Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain;(3)Universitat de Barcelona, Biochemistry and Molecular Biology Department, Barcelona, Spain;(4)Hospital Universitari Mútua Terrassa, Gastroenterology Departament- IBD Unit, Terrassa, Spain;(5)Hospital Universitari Germans Trias i Pujol HUGTP, Gastroenterology Department, Badalona, Spain;(6)Hospital Parc Sanitari Sant Joan de Déu, Surgery Department, Sant Boi de Llobregat, Spain;
P024: Effects of anti-TNF and anti-interleukins 12 and 23 drugs on circulating dendritic cells migratory capacity in inflammatory bowel diseaseECCO’23 CopenhagenYear: 2023
Authors: Soleto, I.(1)*;Ramirez, C.(1);Gómez, C.(1);Montse, B.(1);García, S.(1);Orejudo, M.(1);Mecado, J.(1);Chaparro, M.(1);P. Gisbert, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, gastrointestinal unit, Madrid, Spain;
