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OP06: The influence of different prednisolone tapering algorithms on the effectiveness of infliximab in patients with Ulcerative Colitis – A real-world cohort study
Year: 2022
Source: ECCO'22
Authors: Ovesen, P.D.(1);Ilvemark, J.F.K.F.(1);Attauabi, M.(1);Seidelin, J.B.(1);
Created: Friday, 11 February 2022, 3:52 PM
OP07 The epidemiology of inflammatory bowel diseases among immigrants to Denmark: A population-based cohort study
Year: 2020
Source:

ECCO'20 Vienna

Authors:

M. Agrawal1, S. Shrestha2, G. Corn3, N.M. Nielsen3, M. Frisch3, J.F. Colombel1, T. Jess3

Created: Thursday, 30 January 2020, 10:12 AM
OP07: Absolute and relative risks of kidney and urological complications in patients with Inflammatory Bowel Disease
Year: 2023
Source: ECCO’23 Copenhagen
Authors: Yuanhang Yang
Created: Friday, 14 July 2023, 2:22 PM
OP07: Absolute and relative risks of kidney and urological complications in patients with Inflammatory Bowel Disease
Year: 2023
Source: ECCO’23 Copenhagen
Authors: Yang, Y.(1)*;Ludviggson, J.F.(1,2);Olén, O.(3,4,5);Sjölander, A.(1);Carrero, J.J.(1,6);
Created: Friday, 14 July 2023, 10:43 AM
OP07: Analysing intestinal organoids in a multi-omics, systems biology framework to investigate functional processes affected in Crohn’s disease due to autophagy impairment
Year: 2019
Source:

ECCO '19 Copenhagen

Authors:

L. Gul1, E. Jones1,2, Z. Matthews3, P. Sudhakar1,2,4, A. Treveil1,2, D. Divekar2,3, J. Buck3, M. Jefferson3, S. Armstrong5, A. Watson2,3, S. Carding2,3, U. Mayer6, P. Powell3, I. Hautefort1, T. Wileman2,3, T. Korcsmaros*1,2

Created: Friday, 22 February 2019, 9:41 AM
OP07: Analysing intestinal organoids in a multi-omics, systems biology framework to investigate functional processes affected in Crohn’s disease due to autophagy impairment
Year: 2019
Source: ECCO'19 Copenhagen
Authors: Tamas Korcsmaros
Created: Tuesday, 28 May 2019, 3:32 PM
Autophagy, Proteomics, Transcriptomics, Paneth cells
Files: 1
OP07: Artificial intelligence surpasses gastrointestinal experts in the classification of endoscopic severity among Ulcerative Colitis
Year: 2021
Source: ECCO'21 Virtual
Authors: Lo, B.Z.S.(1);Liu, Z.(1,2);Bendtsen, F.(1);Igel, C.(2);Vind, I.(1);Burisch, J.(1)
Created: Wednesday, 2 June 2021, 4:12 PM
OP07: Artificial intelligence surpasses gastrointestinal experts in the classification of endoscopic severity among Ulcerative Colitis
Year: 2021
Source: ECCO'21 Virtual
Authors: Bobby Zhao Sheng Lo
Created: Friday, 1 October 2021, 12:41 PM
Background

Evaluation of endoscopic disease severity is a key component in the management of ulcerative colitis (UC) patients.  However, endoscopic assessment suffers from substantial intra- and interobserver variation, up to 75 %, thereby limiting the reliability of individual assessments. Our aim was to develop an artificial intelligence (AI) model capable of distinguishing active from healed mucosa as well as to differentiate different levels of endoscopic disease activity.

Methods

1484 unique endoscopic images from 467 patients were extracted for classification. Two experts classified all images independent of each other according to the Mayo endoscopic subscore (MES). In case of disagreement, a third expert classified the images.

Different convolutional neural network architectures were implied in the development of the AI model. Five-fold cross-validation was employed to select the best model. Unseen test data were used for evaluation.

The final model was evaluated on its performance for distinguishing MES 0 from 1–3, MES 0–1 (i.e. mucosal healing) from 2–3, and distinguish between all MES.

The accuracy, sensitivity, specificity, positive and negative predictive value, and Cohen’s Kappa were used to evaluate the final models.

Results

Our final model achieved at the most difficult task (distinguishing between all 4 categories of MES) a mean accuracy of 0.82, mean AUC of 0.99, test accuracy of 0.84, a sensitivity of 0.88, and a specificity of 0.81 and a weighted Cohens Kappa of 0.83 (p<0.001 compared to the experts).

The results from the other tasks are shown in table 1.

Task Test accuracy Sensitivity Specificity PPV NPV Cohens Kappa P-value
Distinguish between all MES 0.84
(0.64–0.96)
0.88
(0.80–0.93)
0.81
(0.73–0.87)
0.80
(0.72–0.86)
0.89
(0.82–0.94)
Unweighted:
0.76 (0.70–0.83)
Weighted:
0.83 (0.79–0.88)
Unweighted:
p<0.001
Weighted:
p<0.001
MES 0 from 1–3 0.94
(0.85–0.97)
0.95
(0.89–0.98)
0.93
(0.87–0.97)
0.94
(0.88–0.97)
0.84
(0.88–0.97)
0.88
(0.82–0.94)
p<0.001
MES 0–11 from 2–3 0.93
(0.84–0.97)
0.78
(0.66–0.87)
0.99
(0.96–1.00)
0.96
(0.86–0.99)
0.93
(0.88–0.96)
0.82
(0.74–0.90) 
p<0.001
*(95 % confidence interval); MES = Mayo endoscopic subscore; PPV = Positive predictive value; NPV = Negative predictive value
1mucosal healing


Conclusion

We propose a new standardised way of evaluating endoscopic images from UC patients for both clinical and academic purposes. The proposed AI model demonstrated a very good capability of distinguishing between all 4 MES levels of activity. This will optimize and unify the evaluation of the disease severity measured by the Mayo endoscopic subscore across all centres and hospitals no matter the level of medical expertise.

OP07: Exploring disease control by combining clinical, biological, and health-related quality of life remission with endoscopic improvements among Ulcerative Colitis patients treated with filgotinib: A post-hoc analysis from the SELECTION trial
Year: 2022
Source: ECCO'22
Authors: Schreiber, S.(1);Feagan, B.(2,3);Peyrin-Biroulet, L.(4);Vermeire, S.(5);Faes, M.(6);Harris, K.(7);Oortwijn, A.(7);Daniele, P.(8);Patel, H.(6);Danese, S.(9,10);
Created: Friday, 11 February 2022, 3:52 PM
OP07: The epidemiology of Inflammatory Bowel Diseases among immigrants to Denmark: a population-based cohort study
Year: 2020
Source: ECCO'20 Vienna
Authors: Manasi Agrawal
Created: Tuesday, 23 June 2020, 5:40 PM
OP07: The epidemiology of Inflammatory Bowel Diseases among immigrants to Denmark: a population-based cohort study
Year: 2020
Source: ECCO'20 Vienna
Authors: Manasi Agrawal
Created: Tuesday, 23 June 2020, 4:58 PM
Files: 1
OP08 Inflammatory bowel disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden
Year: 2020
Source:

ECCO'20 Vienna

Authors:

J. Axelrad1, O. Olen2, M. Sachs2, R. Erichsen3, L. Pedersen3, J. Halfvarson4, J. Askling2, A. Ekbom2, H.T. Sørensen3, J. Ludvigsson5

Created: Thursday, 30 January 2020, 10:12 AM
OP08: Automatic detection of enteric ulcers and erosions in capsule endoscopy using a convolutional neural network
Year: 2021
Source: ECCO'21 Virtual
Authors: SaraivaJr., M.(1);Afonso, J.(1);Ribeiro, T.(1);Cardoso, H.(1);Ferreira, J.(2);Andrade, P.(1);Jorge, R.(2);Lopes, S.(1);Macedo, G.(1)
Created: Wednesday, 2 June 2021, 4:12 PM
OP08: Inflammatory Bowel Disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden
Year: 2020
Source: ECCO'20 Vienna
Authors: Jordan Axelrad
Created: Tuesday, 23 June 2020, 5:40 PM
OP08: Inflammatory Bowel Disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden
Year: 2020
Source: ECCO'20 Vienna
Authors: Jordan Axelrad
Created: Tuesday, 23 June 2020, 4:58 PM
Files: 1
OP08: Long-term efficacy and pharmacodynamics of the anti-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) monoclonal antibody SHP647 in Crohn’s disease: the OPERA II study
Year: 2019
Source:

ECCO '19 Copenhagen

Authors:

G. D’Haens*1, W. Reinisch2, S. D. Lee3, D. Tarabar4, E. Louis5, M. Kłopocka6, J. Klaus7, S. Schreiber8, D. I. Park9, X. Hébuterne10, K. J. Gorelick11, S. W. Martin12, A. Banerjee12, P. Nagy13, Y. Wang14, F. Cataldi14, W. J. Sandborn15

Created: Friday, 22 February 2019, 9:41 AM
OP08: Mucosal healing with vedolizumab in inflammatory bowel disease patients with chronic pouchitis: Evidence from EARNEST, a randomized, double-blind, placebo-controlled trial
Year: 2023
Source: ECCO’23 Copenhagen
Authors: Jairath, V.(1,2)*;Feagan, B.G.(2);Silverberg, M.S.(3);Danese, S.(4);Gionchetti, P.(5);Löwenberg, M.(6);Bressler, B.(7);Ferrante, M.(8);Hart, A.(9);Lindner, D.(10);Escher, A.(10);Jones, S.(10);Shen, B.(11);Travis, S.(12);
Created: Friday, 14 July 2023, 10:43 AM