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Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonistsJCC: Volume 4, Issue 4, 2010
Year: 2010
Authors: Yehuda Chowers, Andreas Sturm, Miquel Sans, Konstantinos Papadakis, Maria Gazouli, Marcus Harbord, Jörg Jahnel, Gerassimos J. Mantzaris, Johannes Meier, Christian Mottet, Laurent Peyrin-Biroulet, Matthieu Allez

This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and mechanisms of action of TNFα antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed.

Understanding the biological activity of tumor-necrosis factor alpha (TNFα) and its available antagonists is essential in order to delineate mechanisms for anti-TNF failures. In this section, we review and discuss the current knowledge regarding possible mechanisms leading to failures of anti-TNF antibodies in the context of their effects at the cellular level, TNF-receptor mediated activities, transmembrane TNF-mediated activities, and the effect of TNFα and anti-TNF agents on different cell types and tissues.

European Crohn’s and Colitis Organisation Topical Review on Treatment Withdrawal [‘Exit Strategies’] in Inflammatory Bowel DiseaseJCC: Volume 12, Issue 1, 2017
Authors: Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, Jarosław Kierkuś, Loris Lopetuso, Edyta Szymanska, Edouard Louis

Clinically effective therapies now exist for remission maintenance in both ulcerative colitis [UC] and Crohn’s Disease [CD]. For each major class of IBD medications [5-aminosalicyclates, immunomodulators, and biologic agents], used alone or in combination, there is a risk of relapse following reduction or cessation of treatment. A consensus expert panel convened by the European Crohn’s and Colitis Organisation [ECCO] reviewed the published literature and agreed a series of consensus practice points. The objective of the expert consensus is to provide evidence-based guidance for clinical practice so that physicians can make informed decisions in partnership with their patients. The likelihood of relapse with stopping each class of IBD medication is reviewed. Factors associated with an altered risk of relapse with withdrawal are evaluated, and strategies to monitor and allow early identification of relapse are considered. In general, patients in clinical, biochemical, and endoscopic remission are more likely to remain well when treatments are stopped. Reintroduction of the same treatment is usually, but not always, successful. The decision to stop a treatment needs to be individualized, and shared decision making with the patient should take place.

Fair Data principles Skills Videos
Year: 2021
Authors: Valérie Pittet
Prevention and Management of Infections in IBD e-Course
Year: 2021
Authors: Stephan Vavricka, Julien Kirchgesner, Thomas Greuter, Bram Verstockt

Upon completion of this case you will:

  • Define which infectious tests (serology, PCR, cultures, …) should be performed at IBD diagnosis, prior to biological/small molecule therapy or while flaring
  • Monitor IBD patients with previous hepatitis B virus infection 
  • Treat Clostridium difficile infection 
  • Advise IBD patients who want to travel 
  • Advise pregnant or breastfeeding IBD patients on vaccination 

Crohn's disease: Perianal disease e-Coursee-Course
Year: 2020
Authors: Federica Furfaro, Kostas Katsanos, Pascal Juillerat, Pierre Ellul

This course has been developed by physicians who had recently participated in the writing of the ECCO Crohn's disease consensus Guidelines. This course is intended for those who are interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to Perianal disease in order to improve patient outcomes.

After this case you will:

  • To appreciate the Crohn’s disease natural history
  • To appreciate the rationale behind specific treatment decisions
  • To understand the right investigations to prescribe to Crohn’s disease patient in specific settings
  • To learn appropriate clinical management of Crohn’s disease patients with perianal involvement

Endoscopy Assessment of the Pouch in IBDSkills Video
Year: 2020
Authors: Marietta Iacucci, Bo Shen
Luminal Crohn's disease e-Coursee-Course
Year: 2020
Authors: João Sabino, Bram Verstockt, Kostas Katsanos, Pascal Juillerat, Pierre Ellul

This course has been developed by physicians who had recently participated in the writing of the ECCO Crohn's disease consensus Guidelines. This course is intended for those who are interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to Luminal disease in order to improve patient outcomes.

Upon completion of this case you will:

  • Know the evidence for induction of remission in mild-to-moderate Crohn’s disease;
  • Know the evidence for maintaining remission in  Crohn’s disease;
  • Know the evidence on how to react upon disease flares, immediately after induction therapy or during maintenance therapy; 
  • Understand the benefits and risks of several medical therapies;
  • Achieve familiarity how to use immunomodulatory agents in mono- or combination therapy;
  • Achieve familiarity how to monitor Crohn’s disease patients who initiated medical therapy or who underwent surgery;
  • Recognise indications for surgical management.

Paediatric CD Treatment e-Coursee-Course
Year: 2020
Authors: Marco Gasparetto, Salvatore Oliva, Patrick van Rheenen

This course has been developed by physicians who had recently participated in the writing of the ECCO Crohn's disease consensus Guidelines. This course is intended for those who are interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to Perianal disease in order to improve patient outcomes.

Upon completion of this case you will:

  • Recognise clinical red flags of paediatric Crohn's and achieve a timely diagnosis
  • Familiarise with the work-up required at IBD diagnosis, including ruling out differential diagnoses
  • Know the current evidence for induction of remission in paediatric Crohn's.
  • Know the current evidence for maintaining remission in paediatric Crohn's.
  • Know how to manage a Crohn's flare in a paediatric patient.
  • Familiarise with how to use immunomodulatory agents in mono or combination therapy and understand the rational behind therapeutic drug monitoring in paediatric Crohn's.
  • Recognise indications for surgical management of paediatric Crohn's and familiarise with the recommended post-operative monitoring.

Endoscopic Assessment and Management of StricturesSkills Videos
Year: 2019
Authors: Henit Yanai

Endoscopic Assessment and Management of Strictures

Endoscopic Scoring in IBD e-Coursee-Course
Year: 2019
Authors: Rosanna Cannatelli, Paolo Gionchetti, Uri Kopylov, Jimmi Limdi, and Marietta Iacucci

This course has been developed for physicians and endoscopists interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to endoscopy in IBD in order to improve patient outcomes.

After this case you will be able to assess:

  • Endoscopic scoring systems in Ulcerative Colitis (UC) 
  • Endoscopic scoring systems to assess Pouchitis 
  • Endoscopic scoring systems in Crohn’s Disease (CD) 
  • Small bowel Crohn’s Disease and capsule endoscopy (CE) 
  • Surveillance colonoscopy in IBD

Endoscopic Scoring Systems in Crohn's DiesaseSkills Videos
Year: 2019
Authors: Marietta Iaccuci

Endoscopic Scoring Systems in Crohn's Diesase

Endoscopic scoring systems in Crohn’s disease Skills Video
Year: 2019
Authors: Marietta Iacucci
Endoscopy assessment and management of stricturesSkills Videos
Year: 2019
Authors: Henit Yanai
Endoscopy Assessment of CD Recurrence: Rutgeerts ScoreSkills Videos
Year: 2019
Authors: Marietta Iaucci
Endoscopy Characterisation of Dysplastic Lesions in IBDSkills Videos
Year: 2019
Authors: Marietta Iaccuci

Endoscopy Characterisation of Dysplastic Lesions in IBD

Ileoanal Pouch CreationSkills Videos
Year: 2019
Authors: Lindsey de Nes and Antonino Spinelli
Ileocaecal CD refractory to medical therapySkills Videos
Year: 2019
Authors: Yves Panis
Ileocolic resection in CDSkills Videos
Year: 2019
Authors: Michel Adamina
Interventional Endoscopy in IBD e-Coursee-Course
Year: 2019
Authors: Marietta Iacucci, Rosanna Cannatelli, Takayuki Matsumoto, Toshio Uraoka, Paulo Kotze, Bo Shen

This course has been developed for physicians and endoscopists interested in Inflammatory Bowel Disease(s) (IBD). One major aim of this e-learning activity is to increase competence and knowledge with regard to endoscopy in IBD in order to improve patient outcomes.

The main learning objective will be to train participants in the evaluation of endoscopic images  of colonic lesions using multiple endoscopic techniques and modalities including the new advanced optical diagnosis technologies: dye chromoendoscopy, dyeless chromoendoscopy, magnification, when and why to do EMR  and ESD. Further this course will detail EMR and ESD techniques and the challenges of ESD and the management of strictures , fistulae and complications in IBD.

The major aim of the endoscopy course is to increase competence, knowledge, and confidence of the participants with regard to interventional therapy and endotherapy  in IBD and to improve patient management and outcomes.

Participants will be trained in the evaluation and interpretation of endoscopic images and videos and in understanding how to assess the situation, how to perform, what to look for, and when and how to treat.